Marschall, A. Hornemann, G.Wubbeler, A.e Hoehl,1 E.Ruhl, B. Kastner, C. Elster1, Compressed FTIR spectroscopy using low-rank matrix reconstruction, Optics Express Vol. 28, Issue 26, pp. 38762-38772 (2020), doi:

Fourier transform infrared (FTIR) spectroscopy is a powerful technique in analytical chemistry. Typically, spatially distributed spectra of the substance of interest are conducted simultaneously using FTIR spectrometers equipped with array detectors. Scanning-based methods such as nearfield-FTIR spectroscopy, on the other hand, are a promising alternative providing higher spatial resolution. However, the serial recording severely limits their application due to long acquisition times and consequential stability issues. We demonstrate that it is possible to heavily reduce the measurement time of scanning methods by applying the mathematical technique of low-rank matrix reconstruction. Data from a previous pilot study of Leishmania strains are analyzed by randomly selecting 5% of the interferometer samples. The obtained results for bioanalytical fingerprinting using the proposed approach are shown to be essentially the same as those obtained from the full set of data. This finding can significantly foster the practical applicability of high-resolution serial scanning techniques in analytical chemistry and is expected to improve also other applications of FTIR spectroscopy and spectromicroscopy.