Deliverable number Deliverable description Deliverable type Delivery date
D1 Standard Operating Procedure (SOP) to assess heating and radioactivity performance of dual functional nanoparticles made of a magnetic shell and a radioactive core Procedure Aug 2020

(M15)

D2 Report on the suitability of the heat delivery systems for hyperthermia treatments (TUS, EMR and MNPs) for use with radiotherapy taking into account the comparison between the modelling outcomes and experimental results from spatial-temporal distribution measurements on tissue-equivalent phantoms Report Nov 2020

(M18)

D3 Report on the characterisation of the irradiation system with radiation and temperature control including temperature uniformity across the sample volume, stability in time and reproducibility Report Mar 2020

(M10)

D4 Paper submitted to a peer reviewed journal on the results of a comparison on the different techniques used to measure the temperature increase due to radiotherapy combined with TUS and EMR and MNP in in vitro and, in silico systems with a target uncertainty of < 10 % Peer reviewed paper Jan 2022

(M32)

D5 Report based on comparison of the in vitro results obtained using hyperthermia (TUS, EM and MNP) combined with radiotherapy on 3D cell cultures to determine the best combination between spatial-temporal radiation-field characteristics and temperature profile Report Apr 2021

(M23)

D6 Paper submitted to a peer reviewed journal on the comparison of the in vivo results obtained using hyperthermia (TUS, EM and MNP) combined with radiotherapy on small animals with different spatial-temporal radiation-field characteristics and different thermal doses. Peer reviewed paper May 2022

(M36)

D7 Paper submitted to a peer reviewed journal on an intercomparative study of different analytical tools that addresses a multimodal approach to the chemical speciation for the biological assessment of MNPs in~/outside tissue matrices. Peer reviewed paper Nov 2021

(M30)

D8 Report on the concepts for model based evaluation of biological equivalent dose for radiotherapy combined with hyperthermia methods which take into account energy deposition in tissues, the radiation dose and the duration of the hyperthermia and/or radiation treatment. Report May 2022

(M36)